PE_PGRS31-S100A9 Interaction Promotes Mycobacterial Survival in Macrophages Through the Regulation of NF-κB-TNF-α Signaling and Arachidonic Acid Metabolism
Sheng Liu, Yan Xie, Wei Luo, Yafeng Dou, Huan Xiong, Zhen Xiao, Xiao‐Lian Zhang
Abstract
Rv1768 promotes mycobacterial survival in macrophages by regulating NF-κB-TNF-α signaling and arachidonic acid metabolism via S100A9. Disturbing the interaction between Rv1768 and S100A9 may be a potential therapeutic target for tuberculosis.
Topics & Concepts
TLR4BiologyArachidonic acidTumor necrosis factor alphaS100A9Signal transductionMicrobiologyCell biologyImmunologyInflammationBiochemistryEnzymeS100 Proteins and AnnexinsImmune Response and InflammationTuberculosis Research and Epidemiology