Triazolization of Enolizable Ketones with Primary Amines: A General Strategy toward Multifunctional 1,2,3‐Triazoles
Rashmi Prakash, Tomas Opsomer, Wim Dehaen
Abstract
The development of metal-free syntheses toward 1,2,3-triazoles has been a burgeoning research area throughout the past decade. Despite the numerous advances, the scarceness of methods for the preparation of 1,5-disubstituted 1,2,3-triazoles from readily available substrates remained a challenge that was addressed by our group in 2016. A metal-free three-component reaction, which we have dubbed the triazolization reaction, was established for the rapid synthesis of 1,5-disubstituted, fully functionalized and NH-1,2,3-triazoles. This novel approach stands out because it utilizes widely available starting materials, namely primary amines and enolizable ketones. Furthermore, the broad substrate scope is a major advantage, and was further expanded by the number of modified protocols that have been reported. Triazolization products have successfully found utility as intermediates in various synthetic transformations, and were the subject of a few interesting biological activity studies.