Transition‐Metal‐Catalyzed Directed C−H Functionalization in/on Water
Tariq A. Shah, Tanumay Sarkar, Subhradeep Kar, Prabhat Kumar Maharana, Kangkan Talukdar, Tharmalingam Punniyamurthy
Abstract
Directing group assisted C-H bond functionalization using transition-metal-catalysis has emerged as a reliable synthetic tool for the construction of regioselective carbon-carbon/heteroatom bonds. Off late, "in/on water directed transition-metal-catalysis", though still underdeveloped, has appeared as one of the prominent themes in sustainable organic chemistry. This article covers the advancements, mechanistic insights and application of the sustainable directed C-H bond functionalization of (hetero)arenes in/on water in the presence of transition-metal-catalysis.
Topics & Concepts
Surface modificationCatalysisTransition metalHeteroatomRegioselectivityChemistryCombinatorial chemistryOrganic chemistryRing (chemistry)Physical chemistryCatalytic C–H Functionalization MethodsAsymmetric Hydrogenation and CatalysisCatalytic Cross-Coupling Reactions