GeneTrail 3: advanced high-throughput enrichment analysis
Nico Gerstner, Tim Kehl, Kerstin Lenhof, Anne Müller, Carolin Mayer, Lea Eckhart, Nadja Grammes, Caroline Diener, Martin Hart, Oliver Hãhn, Jörn Walter, Tony Wyss‐Coray, Eckart Meese, Andreas Keller, Hans‐Peter Lenhof
Abstract
We present GeneTrail 3, a major extension of our web service GeneTrail that offers rich functionality for the identification, analysis, and visualization of deregulated biological processes. Our web service provides a comprehensive collection of biological processes and signaling pathways for 12 model organisms that can be analyzed with a powerful framework for enrichment and network analysis of transcriptomic, miRNomic, proteomic, and genomic data sets. Moreover, GeneTrail offers novel workflows for the analysis of epigenetic marks, time series experiments, and single cell data. We demonstrate the capabilities of our web service in two case-studies, which highlight that GeneTrail is well equipped for uncovering complex molecular mechanisms. GeneTrail is freely accessible at: http://genetrail.bioinf.uni-sb.de.