hnRNP C modulates MERS-CoV and SARS-CoV-2 replication by governing the expression of a subset of circRNAs and cognitive mRNAs
Xi Zhang, Hin Chu, Kenn Ka‐Heng Chik, Lei Wen, Huiping Shuai, Dong Yang, Yixin Wang, Yuxin Hou, Terrence Tsz‐Tai Yuen, Jian‐Piao Cai, Shuofeng Yuan, Feifei Yin, Kwok‐Yung Yuen, Jasper Fuk‐Woo Chan
Abstract
: 1.233 µM) Calu-3 cells with the mTOR inhibitor OSI-027 resulted in significantly reduced viral loads. Collectively, our study identified hnRNP C as a key regulator of MERS-CoV-perturbed circRNAs and their cognate mRNAs, and the potential of targeting hnRNP C-related signalling pathways as an anticoronaviral strategy.
Topics & Concepts
BiologyGene knockdownViral replicationRNA-binding proteinRNASmall interfering RNAVirologyMolecular biologyMessenger RNARibonucleoproteinCell biologyGeneGeneticsVirusCircular RNAs in diseasesMicroRNA in disease regulationRNA Research and Splicing