A naturally occurring mutation in ATP synthase subunit c is associated with increased damage following hypoxia/reoxygenation in STEMI patients
Giampaolo Morciano, Gaia Pedriali, Massimo Bonora, Rita Pavasini, Elisa Mikus, Simone Calvi, Matteo Bovolenta, Magdalena Lebiedzińska, Mirko Pinotti, Alberto Albertini, Mariusz R. Wiȩckowski, Carlotta Giorgi, Roberto Ferrari, Lorenzo Galluzzi, Gianluca Campo, Paolo Pinton
Abstract
and the response to hypoxia/reoxygenation of human cardiomyocytes, which worsen when compared to those expressing the wild-type protein, and a positive correlation between PTPC and RI.
Topics & Concepts
ATP synthaseUniporterHypoxia (environmental)Protein subunitMitochondrial permeability transition poreMutationChemistryBiologyMolecular biologyBiochemistryEnzymeGeneOxygenProgrammed cell deathApoptosisOrganic chemistryCytosolATP Synthase and ATPases ResearchCardiac Ischemia and ReperfusionMitochondrial Function and Pathology