Practicing Antimicrobial Stewardship: De-Escalating Antibiotics in Patients With Acute Myeloid Leukemia and Neutropenic Fever
Risa Fuller, Erin Moshier, Samantha E Jacobs, Douglas Tremblay, Guido Lancman, Alexander Coltoff, Jessica Caro, John Mascarenhas, Meenakshi Rana
Abstract
We compared risk of recurrent fever in patients with acute myeloid leukemia undergoing induction chemotherapy with febrile neutropenia without an infectious source in which antibacterials were de-escalated before neutrophil recovery versus continued. There was less recurrent fever when antibacterials were de-escalated early with no increased adverse events.
Topics & Concepts
MedicineAntimicrobial stewardshipMyeloid leukemiaAntibioticsIntensive care medicineAntimicrobialNeutropeniaInternal medicineMicrobiologyChemotherapyAntibiotic resistanceBiologyNeutropenia and Cancer InfectionsBacterial Identification and Susceptibility TestingHematological disorders and diagnostics