A photoactivatable upconverting nanodevice boosts the lysosomal escape of PROTAC degraders for enhanced combination therapy
Jiayin Zhan, Xiang Li, Yueru Mu, Huiqin Yao, Jun‐Jie Zhu, Jingjing Zhang
Abstract
. This work thus presents a versatile strategy for controlled release of PROTACs and codelivery with photosensitizers using an NIR-responsive nanodevice, providing important insight into the design of effective PROTAC-based combination therapy.
Topics & Concepts
NanodevicePhotodynamic therapyDegradation (telecommunications)ChemistryBiophysicsNanotechnologyMaterials scienceComputer scienceBiologyTelecommunicationsOrganic chemistryProtein Degradation and InhibitorsMultiple Myeloma Research and TreatmentsPeptidase Inhibition and Analysis