Nickel-Catalyzed Asymmetric Hydrogenation for Kinetic Resolution of [2.2]Paracyclophane-Derived Cyclic <i>N</i>-Sulfonylimines
Yang Zhao, Yi‐Xuan Ding, Bo Wu, Yong‐Gui Zhou
Abstract
Nickel-catalyzed asymmetric hydrogenation for kinetic resolution of [2.2]paracyclophane-derived cyclic N-sulfonylimines was successfully developed. High selectivity factors were observed in most cases (s up to 89), providing the recovered materials and hydrogenation products in good yields with high levels of enantiopurity. The recovered materials and hydrogenation products are useful synthetic intermediates for the synthesis of planar chiral [2.2]paracyclophane-based compounds.
Topics & Concepts
NickelKinetic resolutionCatalysisSelectivityAsymmetric hydrogenationChemistryPlanarCombinatorial chemistryKinetic energyMaterials scienceOrganic chemistryEnantioselective synthesisPhysicsComputer scienceQuantum mechanicsComputer graphics (images)Asymmetric Hydrogenation and CatalysisSurface Chemistry and CatalysisCatalysis for Biomass Conversion