Vitamin D May Play a Vital Role in Alleviating Type 2 Diabetes Mellitus by Modulating the Ferroptosis Signaling Pathway
Qiongwen Zhang, Yan Wang, Zi-ying Tong, Cui‐Ping Li, Lianping He
Abstract
Ferroptosis is an iron-dependent death mode mediated by the aggregation of lipid peroxides and lipid-reactive oxygen species. It is characterized by iron-dependent lipid peroxide accumulation accompanied by oxidoreductase deficiency. Pancreatic beta cell dysfunction and insulin resistance are two major causes of type 2 diabetes mellitus (T2DM). Iron accumulation and metabolism may play a role in the development of T2DM. The molecular mechanism of β cell apoptosis and iron death in T2DM were reviewed. In addition, we discuss recent insights on the relationship between the trace element iron and apoptosis of β cells in T2DM.
Topics & Concepts
ApoptosisReactive oxygen speciesLipid peroxideInternal medicineEndocrinologyType 2 Diabetes MellitusInsulin resistanceProgrammed cell deathDiabetes mellitusSignal transductionType 2 diabetesChemistryOxidative stressMedicineBiologyLipid peroxidationBiochemistryPancreatic function and diabetesErythrocyte Function and PathophysiologyMetabolism, Diabetes, and Cancer