Fast and easy conversion of <i>ortho</i> amidoaryldiselenides into the corresponding ebselen-like derivatives driven by theoretical investigations
Vanessa Nascimento, Pâmella Cordeiro, Massimiliano Arca, Francesca Marini, Luca Sancineto, Antônio L. Braga, Vito Lippolis, Michio Iwaoka, Claudio Santi
Abstract
The <italic>in silico</italic> predicted Se⋯N interaction on amidoarylselenenyl iodides has been experimentally exploited for the efficient synthesis of <italic>N</italic>-substituted benzoisoselenazol-3(2<italic>H</italic>)-ones, benzoisothiazol-3(2<italic>H</italic>)-ones and ebselen, recently reported as potent antiviral agent against Sars-Cov2.
Topics & Concepts
ChemistryEbselenStereochemistryOrganic chemistryGlutathione peroxidaseEnzymeGlutathioneOrganoselenium and organotellurium chemistryOrganic Chemistry Cycloaddition ReactionsSulfur-Based Synthesis Techniques