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Discovery of new thieno[2,3-d]pyrimidine and thiazolo[5,4-d]pyrimidine derivatives as orally active phosphoinositide 3-kinase inhibitors

Yan Sun, Rong Fu, Songwen Lin, Jingbo Zhang, Ming Ji, Yan Zhang, Deyu Wu, Kehui Zhang, Hua Tian, Mingyi Zhang, Sheng Li, Yan Li, Jing Jin, Xiaoguang Chen, Heng Xu

2020Bioorganic & Medicinal Chemistry20 citationsDOIOpen Access PDF

Topics & Concepts

PyrimidineChemistryStereochemistryIn vivoPI3K/AKT/mTOR pathwayPharmacologyPharmacokineticsCombinatorial chemistryBiochemistrySignal transductionBiologyBiotechnologyPI3K/AKT/mTOR signaling in cancerChronic Lymphocytic Leukemia ResearchQuinazolinone synthesis and applications
Discovery of new thieno[2,3-d]pyrimidine and thiazolo[5,4-d]pyrimidine derivatives as orally active phosphoinositide 3-kinase inhibitors | Litcius