Activation of mitochondrial DNA-mediated cGAS-STING pathway contributes to chronic postsurgical pain by inducing type I interferons and A1 reactive astrocytes in the spinal cord
Yuye Chen, Yingjie Hu, Xiao He, Hu Zang, Rao Sun, Chang Zhu, Wenlong Yao
Topics & Concepts
StingSpinal cordPharmacologyCyclic guanosine monophosphateMitochondrial DNAMitochondrionMicrogliaMedicineChemistryImmunologyCell biologyBiologyInflammationInternal medicineBiochemistryNeuroscienceGeneNitric oxideEngineeringAerospace engineeringInflammasome and immune disordersPain Mechanisms and Treatmentsinterferon and immune responses