Major and minor salivary gland cancers: A multicenter retrospective study
Muhammet Bekir Hacıoğlu, Bülent Erdoğan, Murat Bardakçı, Efnan Algın, Burcu Gülbağcı, İlhan Hacıbekiroğlu, Jamshid Hamdard, Ömer Fatih Ölmez, Hadi Akkus, Berna Öksüzoğlu, Sema Sezgin Göksu, Shute Ailia Dae, Ahmet Taner Sümbül, Muzaffer Uğraklı, Mustafa Karaağaç, Elif Şahin, Devrim Çabuk, Özden Özer, Tuğba Yavuzşen, Rukiye Arıkan, Osman Köstek, Muhammed Mustafa Atçı, Abdullah Sakin, Adem Deligönül, Duygu Bayır, Murat Dinçer, Oktay Ünsal, Ozan Yazıcı, Esra Zeynelgil, Ahmet Gülmez, Hakan Harputluoğlu, Cihan Erol, Mehmet Alı Nahıt Şendur, Aydın Aytekin, Baran Akagündüz, İrem Öner, Özlem Er, Buğra Öztosun, Mahmut Gümüş, Fatih Selçukbırıcık, Musa Barış Aykan, Nuri Karadurmuş, Ezgi Değerli, Nebi Serkan Demirci, Esma Türkmen, Teoman Şakalar, Şaban Seçmeler, Özgür Tanrıverdi, Ali Alkan, Yasemi̇n Kemal, İbrahim Çil, Çağlar Ünal, Yakup İriağaç, Özkan Alan, Sevinç Ballı, Yüksel Ürün, Erkan Özcan, Nazım Serdar Turhal, İrfan Çiçin
Abstract
BACKGROUND: Most of the studies on salivary gland cancers are limited for various reasons such as being single-center, small number of patients, including only major or minor SGCs, or only including epidemiological data. METHODS: A total of 37 medical oncology clinics from different regions of Turkey participated in this retrospective-multicenter study. The analyzed data included clinical and demographical features, primary treatment, metastasis localizations, and treatments and includes certain pathologic features. RESULTS: The study included data from a total of 443 SGCs. 56.7% was in major salivary glands and 43.3% was in minor salivary glands. Distant metastasis in the major SGCs was statistically significantly more common than in the minor SGCs, locoregional recurrence was statistically significantly more common in the minor SGCs than in the major SGCs (p = 0.003). CONCLUSIONS: Epidemiological information, metastasis and recurrence patterns, treatment modalities, and survival analysis of the patients over 20 years of follow-up are presented.