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Small Molecule Inhibition of CPS1 Activity through an Allosteric Pocket

Shihua Yao, Tuong-Vi Nguyen, Alan Rolfe, Anant A. Agrawal, Jiyuan Ke, Shouyong Peng, Federico Colombo, Sean Yu, Patricia Bouchard, Jiayi Wu, Kuan-Chun Huang, Xingfeng Bao, Kiyoyuki Omoto, Anand Selvaraj, Lihua Yu, Stephanos Ioannidis, Frédéric H. Vaillancourt, Ping Zhu, Nicholas Larsen, David M. Bolduc

2020Cell chemical biology43 citationsDOIOpen Access PDF

Topics & Concepts

Allosteric regulationCarbamoyl phosphate synthetaseChemistrySmall moleculeAmmoniaBiochemistryPharmacologyEnzymeBiologyBiochemical and Molecular ResearchCancer, Hypoxia, and MetabolismEpigenetics and DNA Methylation
Small Molecule Inhibition of CPS1 Activity through an Allosteric Pocket | Litcius