ROS induced the Rab26 promoter hypermethylation to promote cigarette smoking-induced airway epithelial inflammation of COPD through activation of MAPK signaling
Binfeng He, Yixing Wu, Weiping Hu, Jian-lan Hua, Han Yao-ping, Jing Zhang
Topics & Concepts
COPDDNA methylationGene silencingp38 mitogen-activated protein kinasesRespiratory epitheliumInflammationDNMT3BIn vivoMAPK/ERK pathwayCancer researchChemistryImmunologyMethylationMedicinePharmacologyLungSignal transductionBiologyGene expressionInternal medicineBiochemistryDNAGeneBiotechnologyChronic Obstructive Pulmonary Disease (COPD) ResearchPediatric health and respiratory diseasesNeuroscience of respiration and sleep