The exon-junction complex helicase eIF4A3 controls cell fate via coordinated regulation of ribosome biogenesis and translational output
Dimitris C. Kanellis, Jaime A. Espinoza, Asimina Zisi, Elpidoforos Sakkas, Jiřina Bártková, Anna‐Maria Katsori, Johan Boström, Lars Dyrskjøt, Helle Broholm, Mikael Altun, Simon J. Elsässer, Mikael S. Lindström, Jiří Bártek
Abstract
) transcript isoforms that control p53. EIF4A3 expression and subnuclear localization among clinical cancer specimens correlate with the RiBi status rendering eIF4A3 an exploitable vulnerability in high-RiBi tumors. We propose a concept of eIF4A3's unexpected role in RiBi, with implications for cancer pathogenesis and treatment.
Topics & Concepts
HelicaseRibosome biogenesisBiogenesisRibosomeRNA Helicase ABiologyCell biologyGeneticsRNAGeneCRISPR and Genetic EngineeringRNA and protein synthesis mechanismsRNA Research and Splicing