Targeted metabolomics combined with network pharmacology to reveal the protective role of luteolin in pulmonary arterial hypertension
Kexin Song, Qingya Duan, Jiping Ren, Jie Yi, Hong Yu, Haixia Che, Chunjuan Yang, Xiaotong Wang, Qian Li
Abstract
-acetyl-L-ornithine, butane diacid, ornithine, glutamic acid metabolites in amino acid and TCA pathways. However, treatment with luteolin recovered the LTB4, PGE2, PGD2, 12-HETE, 15-HETE, PGF2α and 8-iso-PGF2α levels close to normal. Meanwhile, we showed that luteolin also downregulated the gene and protein levels of COX 1, 5-LOX, 12-LOX, and 15-LOX in the arachidonic acid pathway. Collectively, this work highlighted the metabolic mechanism of luteolin-protected PAH and showed that luteolin would hold great potential in PAH prevention.
Topics & Concepts
Arachidonic acidLuteolinPharmacologyGlycolysisChemistryBiochemistryMetabolismMedicineQuercetinEnzymeAntioxidantPulmonary Hypertension Research and TreatmentsEicosanoids and Hypertension PharmacologyMetabolomics and Mass Spectrometry Studies