Nickel-catalyzed enantioselective umpolung hydrogenation for stereoselective synthesis of β-amido esters
Jianrong Steve Zhou, Siyu Guo, Xiaohu Zhao, Yonggui Robin
Abstract
Nickel complexes ligated by strongly donating diphosphines catalyze enantioselective hydrogenation for the preparation of acyclic and cyclic β-amido esters. A combination of acetic acid and indium powder provides protons and electrons to form nickel hydrido complexes under umpolung hydrogenation conditions.
Topics & Concepts
UmpolungEnantioselective synthesisNickelDiphosphinesChemistryCatalysisStereoselectivityAsymmetric hydrogenationIndiumOrganic chemistryAcetic acidCombinatorial chemistryNucleophileAsymmetric Hydrogenation and CatalysisChemical Synthesis and AnalysisSurface Chemistry and Catalysis