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Loss of p53 and mutational heterogeneity drives immune resistance in an autochthonous mouse lung cancer model with high tumor mutational burden

Mingrui Zhu, Jiwoong Kim, Qing Deng, Biagio Ricciuti, Joao V. Alessi, Buse Eglenen-Polat, Matthew E. Bender, Hai-Cheng Huang, Ryan R. Kowash, Ileana Cuevas, Zachary T. Bennett, Jinming Gao, John D. Minna, Diego H. Castrillón, Mark M. Awad, Lin Xu, Esra A. Akbay

2023Cancer Cell56 citationsDOIOpen Access PDF

Topics & Concepts

BiologyImmune systemCancer researchLung cancerMutationCancerImmunologyGeneticsTumor heterogeneityGeneMedicineOncologyCancer Immunotherapy and BiomarkersCancer Genomics and DiagnosticsFerroptosis and cancer prognosis
Loss of p53 and mutational heterogeneity drives immune resistance in an autochthonous mouse lung cancer model with high tumor mutational burden | Litcius