Loss of p53 and mutational heterogeneity drives immune resistance in an autochthonous mouse lung cancer model with high tumor mutational burden
Mingrui Zhu, Jiwoong Kim, Qing Deng, Biagio Ricciuti, Joao V. Alessi, Buse Eglenen-Polat, Matthew E. Bender, Hai-Cheng Huang, Ryan R. Kowash, Ileana Cuevas, Zachary T. Bennett, Jinming Gao, John D. Minna, Diego H. Castrillón, Mark M. Awad, Lin Xu, Esra A. Akbay
Topics & Concepts
BiologyImmune systemCancer researchLung cancerMutationCancerImmunologyGeneticsTumor heterogeneityGeneMedicineOncologyCancer Immunotherapy and BiomarkersCancer Genomics and DiagnosticsFerroptosis and cancer prognosis