Control of Intestinal Epithelial Permeability by Lysophosphatidic Acid Receptor 5
Mo Wang, Peijian He, Yiran Han, Lei Dong, C. Chris Yun
Abstract
BACKGROUND & AIMS: in regulation of intestinal epithelial barrier. METHODS: -mediated signaling pathways that regulate epithelial barrier. RESULTS: transcriptionally regulated claudin-4, and this regulation was dependent on transactivation of the epidermal growth factor receptor, which induced localization of Rac1 at the cell membrane. LPA induced the translocation of Stat3 to the cell membrane and promoted the interaction between Rac1 and Stat3. Inhibition of Stat3 ablated LPA-mediated regulation of claudin-4. CONCLUSIONS: promotes claudin-4 expression in IECs through activation of Rac1 and Stat3.
Topics & Concepts
Lysophosphatidic acidIntestinal epitheliumCell biologyBarrier functionIntestinal mucosaIntestinal permeabilityChemistryRAC1ReceptorOccludinCaco-2LipopolysaccharideTight junctionBiologyEpitheliumSignal transductionCellBiochemistryInternal medicineImmunologyMedicineGeneticsBarrier Structure and Function StudiesSphingolipid Metabolism and SignalingDrug Transport and Resistance Mechanisms