Alkali-amide controlled selective synthesis of 7-azaindole and 7-azaindoline through domino reactions of 2-fluoro-3-methylpyridine and aldehydes
Xinyu Xu, Mingjie Ou, Yan‐En Wang, Tingzhi Lin, Dan Xiong, Fei Xue, Patrick J. Walsh, Jianyou Mao
Abstract
An alkali counterion controlled chemoselective synthesis of 7-azaindole and 7-azaindoline has been demonstrated.
Topics & Concepts
ChemistryAlkali metalAmideCounterionCombinatorial chemistryOrganic chemistryDominoCatalysisIonCancer therapeutics and mechanismsSynthesis and pharmacology of benzodiazepine derivativesQuinazolinone synthesis and applications