Underestimation of Follow-Up Infarct Volume by Acute CT Perfusion Imaging
Jelle Demeestere, Benjamin F.J. Verhaaren, Sören Christensen, Anke Wouters, Gregory W. Albers, Maarten G. Lansberg, Robin Lemmens
Abstract
BACKGROUND AND OBJECTIVES: It is unknown whether acute CT perfusion (CTP) core imaging may underestimate the follow-up infarct. We hypothesize that infarct underestimation occurs especially in late-presenting patients and that underestimated infarct can partially be detected on baseline noncontrast CT (NCCT). METHODS: ) and used the relative cerebral blood flow <30% to segment the CTP core. On coregistered images, we performed volumetric and voxel-based analyses to compare infarct estimations by imaging modality. Spatial accuracy for the follow-up infarct was assessed using the Dice similarity coefficient (DSC) and balanced accuracy. RESULTS: < 0.001 for both). DISCUSSION: and CTP increases the accuracy for predicting the follow-up infarct.