The Role of Complement in Myocardial Infarction Reperfusion Injury: An Underappreciated Therapeutic Target
Carl‐Wilhelm Vogel
Abstract
This article reviews the pathogenetic role of the complement system in myocardial infarction reperfusion injury. The complement activation pathways involved in myocardial tissue injury are identified, as are the complement-derived effector molecules. The results of past anti-complement therapies are reviewed; as the more recent therapeutic concept of complement depletion with humanized CVF described.
Topics & Concepts
Complement systemComplement (music)Myocardial infarctionMedicineEffectorReperfusion injuryImmunologyCardiologyBiologyIschemiaAntibodyGeneBiochemistryComplementationPhenotypeComplement system in diseasesNeutrophil, Myeloperoxidase and Oxidative MechanismsVenomous Animal Envenomation and Studies