Activation of the cGAS-STING pathway by a mitochondrial DNA-targeted emissive rhodium(<scp>iii</scp>) metallointercalator
Yue Zheng, Xiaoxiao Chen, Dongyang Zhang, Wenjin Wang, Kun Peng, Zhiyuan Li, Zong‐Wan Mao, Cai‐Ping Tan
Abstract
by intravenous injection. Overall, we report for the first time that small molecules targeting mtDNA can activate the cGAS-STING pathway, which gives insights into the development of biomacromolecule-targeted immunotherapeutic agents.
Topics & Concepts
Stimulator of interferon genesMitochondrial DNAMitochondrionBiologyInnate immune systemInterferonCell biologyCancer immunotherapySignal transductionImmune systemChemistryImmunotherapyGeneBiochemistryGeneticsinterferon and immune responsesRNA modifications and cancerRNA regulation and disease