IL-23, but not IL-12, plays a critical role in inflammation-mediated bone disorders
Jiajia Xu, Jian Li, Yiming Hu, Kerong Dai, Yaokai Gan, Jingyu Zhao, Mingjian Huang, Xiaoling Zhang
Abstract
: These data collectively uncover a previously unrecognized role of IL-23 in skeletal tissue engineering. Thus, IL-23 can act as a biomarker to predict diseases and treatment efficacy, and apilimod can be used as an effective therapeutic drug to combat inflammatory bone disorders.
Topics & Concepts
InflammationInterleukin 23MedicineImmunologyInterleukin 17Psoriasis: Treatment and PathogenesisSpondyloarthritis Studies and TreatmentsBone Metabolism and Diseases