Protein Kinase C Isozymes and Autophagy during Neurodegenerative Disease Progression
Hümeyra Nur Kaleli, Ebru Ozer, Veysel Oğulcan Kaya, Özlem Kutlu
Abstract
Protein kinase C (PKC) isozymes are members of the Serine/Threonine kinase family regulating cellular events following activation of membrane bound phospholipids. The breakdown of the downstream signaling pathways of PKC relates to several disease pathogeneses particularly neurodegeneration. PKC isozymes play a critical role in cell death and survival mechanisms, as well as autophagy. Numerous studies have reported that neurodegenerative disease formation is caused by failure of the autophagy mechanism. This review outlines PKC signaling in autophagy and neurodegenerative disease development and introduces some polyphenols as effectors of PKC isozymes for disease therapy.
Topics & Concepts
AutophagyNeurodegenerationIsozymeProtein kinase CCell biologyKinaseBiologySignal transductionProgrammed cell deathMechanism (biology)Protein kinase ADiseaseBiochemistryMedicineEnzymeApoptosisPathologyEpistemologyPhilosophyAutophagy in Disease and TherapyCalcium signaling and nucleotide metabolismSirtuins and Resveratrol in Medicine