IgG-cleaving endopeptidase enables in vivo gene therapy in the presence of anti-AAV neutralizing antibodies
Christian Leborgne, Elena Barbon, J M Alexander, Hayley A. Hanby, Sandrine Delignat, Daniel M. Cohen, Fanny Collaud, Saghana Muraleetharan, Dan Lupo, Joseph Silverberg, Karen Huang, Laetitia van Wittengerghe, Béatrice Marolleau, Adeline Miranda, Anna Fabiano, Victoria Daventure, Heena Beck, Xavier M. Anguela, Giuseppe Ronzitti, Sean M. Armour, Sébastien Lacroix‐Desmazes, Federico Mingozzi
Topics & Concepts
Genetic enhancementAntibodyIn vivoAdeno-associated virusVirologyVirusVectors in gene therapyIn vitroNeutralizing antibodyImmunologyBiologyImmunoglobulin GImmunosuppressionMedicineViral vectorVector (molecular biology)GeneRecombinant DNABiotechnologyBiochemistryVirus-based gene therapy researchRNA Interference and Gene DeliveryVirology and Viral Diseases