Prognostic value and immunological roles of GPX3 in gastric cancer
Qijin He, Na Chen, Xu Wang, Ping Li, Limin Liu, Zheng Rong, Wentian Liu, Kui Jiang, Jingwen Zhao
Abstract
Collectively, we hypothesized that the potential involvement of non-coding RNAs in the downregulation of GPX3 could contribute to the inhibition of tumor formation during the malignant transition from gastritis to GC. Nevertheless, it was plausible that GPX3 may also facilitate tumor progression to advanced stages by promoting immune cell infiltration and activating immune checkpoints.
Topics & Concepts
GPX3Computational biologyBiologyCancer researchGlutathioneGlutathione peroxidaseBiochemistryEnzymeCancer-related molecular mechanisms researchFerroptosis and cancer prognosisCircular RNAs in diseases