Megabase-scale loss of heterozygosity provoked by CRISPR-Cas9 DNA double-strand breaks
Samantha B. Regan, Darpan Medhi, Yuanlin Xu, Travis White, Yi-Zhen Jiang, Jung Eun Kim, Shih-Chun Wang, Qichen Deng, Jia Su, Dulguun Baasan, Jon P. Connelly, Ti-Cheng Chang, Shondra M. Pruett‐Miller, Maria Jasin
Topics & Concepts
BiologyLoss of heterozygosityTelomereDNAGeneGeneticsEmbryonic stem cellCell biologyChromosomeDNA damageMolecular biologyTelomeraseGenome editingDNA repairCellHEK 293 cellsCRISPRTumor suppressor geneRegulation of gene expressionCell cultureCRISPR and Genetic EngineeringRNA regulation and diseaseVirus-based gene therapy research