Insights into the associations between the gut microbiome, its metabolites, and heart failure
Adilah F. Ahmad, José A. Caparrós‐Martín, Nicola Gray, Samantha Lodge, Julien Wist, Silvia Lee, Fergal O’Gara, Amit Shah, Natalie C. Ward, Girish Dwivedi
Abstract
We found a reduction in gut bacterial alpha diversity in patients with heart failure (HF) and that the stool microbiota of patients with HF was characterized by depletion of operational taxonomic units representing commensal Clostridia at both baseline and follow-up. Patients with HF also had altered bacterial metabolites and increased inflammatory profiles compared with healthy controls. A distinct metabolomic and lipidomic profile was present in patients with HF at baseline when compared with healthy controls.
Topics & Concepts
ClostridiaHeart failureMicrobiomeGut microbiomeGut floraMetabolomicsGut microfloraInternal medicineBiologyPhysiologyMedicineMicrobiologyGastroenterologyBioinformaticsImmunologyBacteriaGeneticsGut microbiota and healthClostridium difficile and Clostridium perfringens researchDiet and metabolism studies