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A physiologically based pharmacokinetic - pharmacodynamic modelling approach to predict incidence of neutropenia as a result of drug-drug interactions of paclitaxel in cancer patients

Maïlys De Sousa Mendes, Oliver Hatley, Katherine L. Gill, Karen Rowland Yeo, Alice Ke

2020European Journal of Pharmaceutical Sciences18 citationsDOI

Topics & Concepts

Physiologically based pharmacokinetic modellingPharmacologyPharmacokineticsNeutropeniaPaclitaxelMedicinePharmacodynamicsDocetaxelNONMEMConcomitantPopulationDrugCYP3A4CYP2C8KetoconazoleInternal medicineCancerChemotherapyCytochrome P450AntifungalMetabolismEnvironmental healthDermatologyNeutropenia and Cancer InfectionsCancer Treatment and PharmacologyPancreatic and Hepatic Oncology Research
A physiologically based pharmacokinetic - pharmacodynamic modelling approach to predict incidence of neutropenia as a result of drug-drug interactions of paclitaxel in cancer patients | Litcius