Ratiometric pH Imaging Using a 1,2-Dioxetane Chemiluminescence Resonance Energy Transfer Sensor in Live Animals
Lucas S. Ryan, Jeni Gerberich, Uroob Haris, Daphne M. Nguyen, Ralph P. Mason, Alexander R. Lippert
Abstract
into live mice show high photon outputs and consistent increases in the flux ratio when measured at pH 6, 7, and 8.
Topics & Concepts
ChemiluminescenceChemistryDioxetaneLuminescenceFluorophorePhotochemistryEnergy transferAnalytical Chemistry (journal)BiophysicsFluorescenceMaterials scienceOpticsChromatographyOptoelectronicsBiologyPhysicsMolecular physicsAnalytical Chemistry and SensorsNitric Oxide and Endothelin EffectsNanoplatforms for cancer theranostics