Tumor collection/processing under physioxia uncovers highly relevant signaling networks and drug sensitivity
Brijesh Kumar, Adedeji K. Adebayo, Mayuri Prasad, Maegan L. Capitano, Ruizhong Wang, Poornima Bhat‐Nakshatri, Manjushree Anjanappa, Edward Simpson, Duojiao Chen, Yunlong Liu, Jeanne M. Schilder, Austyn Colter, Callista Maguire, Constance J. Temm, George E. Sandusky, Emma H. Doud, Aruna Wijeratne, Amber L. Mosley, Hal E. Broxmeyer, Harikrishna Nakshatri
Abstract
compared to ambient air display distinct differences in key signaling networks including LGR5/WNT, YAP, and NRF2/KEAP1, nuclear reactive oxygen species, alternative splicing, and sensitivity to targeted therapies. Therefore, evaluating cancer cells under physioxia could more closely recapitulate their physiopathologic status in the in vivo microenvironment.
Topics & Concepts
DrugSensitivity (control systems)Atmospheric oxygenDrug responseMedicineComputational biologyComputer scienceBioinformaticsBiologyOxygenPharmacologyChemistryEngineeringOrganic chemistryElectronic engineeringCancer, Hypoxia, and MetabolismHippo pathway signaling and YAP/TAZCancer-related Molecular Pathways