Visible Light-Promoted Radical Relay Cyclization/C–C Bond Formation of <i>N</i>-Allylbromodifluoroacetamides with Quinoxalin-2(1<i>H</i>)-ones
Zhipeng Ye, Fang Liu, Xinyu Duan, Jie Gao, Jianping Guan, Jun‐An Xiao, Hao‐Yue Xiang, Kai Chen, Hua Yang
Abstract
A visible light-promoted radical relay of N-allylbromodifluoroacetamide with quinoxalin-2(1H)-ones was developed in which 5-exo-trig cyclization and C–C bond formation were involved. This protocol was performed under mild conditions to facilely offer a variety of hybrid molecules bearing both quinoxalin-2(1H)-one and 3,3-difluoro-γ-lactam motifs. These prepared novel skeletons would expand the accessible chemical space for structurally complex heterocycles with potential biological activities.
Topics & Concepts
RelayChemistryVisible spectrumMoleculeRadical cyclizationStereochemistryCombinatorial chemistryMaterials sciencePhysicsOrganic chemistryOptoelectronicsQuantum mechanicsPower (physics)Fluorine in Organic ChemistryRadical Photochemical ReactionsSynthesis and Biological Evaluation