Carboxylic Acid Transporters in <i>Candida</i> Pathogenesis
Rosana Maria Abreu Alves, Maria Sousa-Silva, Daniel Vieira, Pedro Soares, Yasmin Chebaro, Michael Lorenz, Margarida Casal, Isabel Soares‐Silva, Sandra Paiva
Abstract
Opportunistic pathogens such as Candida species can use carboxylic acids, like acetate and lactate, to survive and successfully thrive in different environmental niches. These nonfermentable substrates are frequently the major carbon sources present in certain human body sites, and their efficient uptake by regulated plasma membrane transporters plays a critical role in such nutrient-limited conditions. Here, we cover the physiology and regulation of these proteins and their potential role in Candida virulence.
Topics & Concepts
VirulenceTransporterMicrobiologyPathogenesisBiologyChemistryVirulence factorBacteriaBiochemistryGeneImmunologyGeneticsAntifungal resistance and susceptibilityPneumocystis jirovecii pneumonia detection and treatmentPolyamine Metabolism and Applications