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EZH2 inhibition activates a dsRNA–STING–interferon stress axis that potentiates response to PD-1 checkpoint blockade in prostate cancer

Katherine L. Morel, Anjali V. Sheahan, Deborah L. Burkhart, Sylvan C. Baca, Nadia Boufaied, Yin Liu, Xintao Qiu, Israel Cañadas, Kevin Roehle, Max Heckler, Carla Calagua, Huihui Ye, Constantia Pantelidou, Phillip M. Galbo, Sukanya Panja, Antonina Mitrofanova, Scott Wilkinson, Nichelle C. Whitlock, Shana Y. Trostel, Anis Hamid, Adam S. Kibel, David A. Barbie, Atish D. Choudhury, Mark M. Pomerantz, Christopher J. Sweeney, Henry W. Long, David J. Einstein, Geoffrey I. Shapiro, Stephanie K. Dougan, Adam G. Sowalsky, Housheng Hansen He, Matthew L. Freedman, Steven P. Balk, Massimo Loda, David P. Labbé, Brian M. Olson, Leigh Ellis

2021Nature Cancer241 citationsDOIOpen Access PDF

Topics & Concepts

Stimulator of interferon genesProstate cancerCancer researchEZH2InterferonBlockadeImmune checkpointCancerCD8ChemokineMedicineImmunologyImmunotherapyBiologyImmune systemInnate immune systemInternal medicineReceptorGene expressionGeneBiochemistryinterferon and immune responsesCancer-related molecular mechanisms researchRNA modifications and cancer
EZH2 inhibition activates a dsRNA–STING–interferon stress axis that potentiates response to PD-1 checkpoint blockade in prostate cancer | Litcius