Ilaprazole and Other Novel Prazole-Based Compounds That Bind Tsg101 Inhibit Viral Budding of Herpes Simplex Virus 1 and 2 and Human Immunodeficiency Virus from Cells
Jonathan Leis, Chi‐Hao Luan, James E. Audia, Sara F. Dunne, Carissa M. Heath
Abstract
These results provide the basis for the development of drugs that target enveloped virus budding that can be used ultimately to control multiple virus infections in humans.
Topics & Concepts
BiologyHerpes simplex virusVirologyTSG101VirusHuman immunodeficiency virus (HIV)Viral entryViral replicationGeneticsGenemicroRNAMicrovesiclesHerpesvirus Infections and TreatmentsCytomegalovirus and herpesvirus researchHIV Research and Treatment