RETRACTED: Effects of commonly used food additives on haematological parameters of Wistar rats
Oluwabunmi P. Femi-Oloye, Afolabi Owoloye, Adetola Mary Olatunji-Ojo, Adetoye Clement Abiodun, Bamidele Adewumi, Babatunde Oluwaseun Ibitoye, Femi F. Oloye, Joshua Idowu Izegaegbe, Tobi Musa Adebayo, Ademola Joseph Adedoja, Oyindamola Precious Oginni, Francis Ayodeji Gbore, Felix Olusegun Akinwumi
Abstract
+ 10 mg of AA, respectively for 21 non-consecutive days. At the end of the experiment, blood samples were collected in EDTA anticoagulant tubes, haematological parameters were evaluated, and data were analyzed. There was a dose-dependent increase (p < 0.05) in White Blood Cell counts of SB treated rats compared with the control group. The lymphocyte exhibited significant reduction (p < 0.05) in the groups treated with 1mg SB and 10mg SB/kg bodyweight of 67 ± 2.96 and 58 ± 4.18%, respectively. The mean corpuscular haemoglobin showed no significant difference at 95% confidence interval. However, mean corpuscular haemoglobin concentration, haematocrit and platelet were affected by an increase in the concentrations of SB. High SB concentrations increased the destruction of erythrocytes, which directly increased the catabolism of haemoglobin. However, AA administration mitigated the adverse effects of SB on the haematological parameters of the animal.