Multimerized self-assembled caged<i>two-in-one</i>siRNA nanoparticles for photomodulation of RNAi-induced gene silencing
Changmai Chen, Nannan Jing, Zhongyu Wang, Yu Zhang, Wei Chen, Xinjing Tang
Abstract
caged Multi-Chol-siGFP/siEg5 self-assembled nanoparticles simultaneously targeting GFP and Eg5 genes were also developed. The caged Multi-Chol-siRNA self-assembled nanoparticles have demonstrated the effectiveness of enhancing photomodulation of multiple RNAi-induced gene silencing activities in cells.
Topics & Concepts
Gene silencingRNA interferenceSmall interfering RNAChemistryNanoparticleInterference (communication)Cell biologyRNA silencingGeneTransfectionRNANanotechnologyBiologyBiochemistryMaterials scienceTelecommunicationsComputer scienceChannel (broadcasting)Photochromic and Fluorescence ChemistryPolydiacetylene-based materials and applicationsRNA Interference and Gene Delivery