COAP/Pd-Catalyzed Linear Asymmetric Allylic Alkylation for Optically Active 3,3-Disubstituted Oxindole Derivatives with a Four-Carbon Amino Side Chain
Wenkai Liu, Bailin Wang, Sheng‐Suo Zhou, Jun-Hao Shen, Zheng Wang, Xing‐Wang Wang
Abstract
An asymmetric linear selective allylic alkylation of vinylaziridines with 3-aryl oxindoles has been developed by using a chiral oxamide-phosphine (COAP-Bn-OMe-p)/palladium complex in methanol, which furnished a wide variety of 3,3-disubstituted oxindole derivatives in good yields with excellent regio- and enantioselectivities.
Topics & Concepts
ChemistryOxindoleTsuji–Trost reactionAllylic rearrangementCatalysisArylPalladiumPhosphineEnantioselective synthesisAsymmetric carbonAlkylationOptically activeCombinatorial chemistryStereochemistryOrganic chemistryAlkylAsymmetric Synthesis and CatalysisCatalytic C–H Functionalization MethodsAsymmetric Hydrogenation and Catalysis