Visible Light Assisted Direct C3–H Arylation of Pyrido[1,2-<i>a</i>]pyrimidin-4-ones and Thiazolo[3,2-<i>a</i>]pyrimidin-5-ones
Rajesh T. Bhawale, Umesh A. Kshirsagar
Abstract
Metal-catalyst-free, organic dye-catalyzed C3–H arylation of pyrido[1,2- a ]pyrimidin-4-ones using visible light irradiation was developed under mild reaction conditions. This operationally simple and direct C–H functionalization approach effectively produced biologically significant C3 arylated pyrido[1,2- a ]pyrimidin-4-one and thiazolo[3,2- a ]pyrimidin-5-one derivatives, including medicinally important endothelial cell dysfunction inhibitor and anti-inflammatory agents in good to excellent yields with good functional group tolerance. The present photoinduced direct C3–H arylation approach was suitable for scale-up synthesis.
Topics & Concepts
Combinatorial chemistryFunctional groupSurface modificationCatalysisChemistryReaction conditionsVisible spectrumIrradiationMaterials scienceOrganic chemistryOptoelectronicsPhysical chemistryPhysicsNuclear physicsPolymerCatalytic C–H Functionalization MethodsRadical Photochemical ReactionsSulfur-Based Synthesis Techniques