E2F1 promotes proliferation and metastasis of clear cell renal cell carcinoma via activation of SREBP1-dependent fatty acid biosynthesis
Donglai Shen, Yu Gao, Qingbo Huang, Yundong Xuan, Yuanxin Yao, Liangyou Gu, Yan Huang, Yu Zhang, Pin Li, Fan Yang, Lu Tang, Songliang Du, Shengpan Wu, Hanfeng Wang, Chenfeng Wang, Huijie Gong, Yuewen Pang, Xin Ma, Baojun Wang, Xu Zhang
Topics & Concepts
Sterol regulatory element-binding proteinCell growthE2F1Cancer researchClear cell renal cell carcinomaLipid metabolismDownregulation and upregulationFatty acid synthesisBiologyCell cycleEpithelial–mesenchymal transitionCell biologyChemistryCellTranscription factorBiochemistryInternal medicineFatty acidRenal cell carcinomaMedicineGeneCancer, Lipids, and MetabolismFerroptosis and cancer prognosisRNA modifications and cancer