Centrosomal protein 120 promotes centrosome amplification and gastric cancer progression via USP54-mediated deubiquitination of PLK4
Chenggang Zhang, Xianxiong Ma, Guanxin Wei, Xiuxian Zhu, Peng Hu, Xiang Chen, Dianshi Wang, Yuan Li, Tuo Ruan, Weikang Zhang, Kaixiong Tao, Chuanqing Wu
Abstract
. We demonstrated that CEP120 promotes centrosome amplification and GC progression by promoting the expression and centrosome aggregation of the deubiquitinating enzyme USP54, maintaining the stability of PLK4 and reducing its ubiquitination degradation. In conclusion, the CEP120-USP54-PLK4 axis may play an important role in promoting centrosome amplification and GC progression, thus providing a potential therapeutic target for GC.
Topics & Concepts
CentrosomeDeubiquitinating enzymeCell biologyCarcinogenesisUbiquitinBiologyTumor progressionChemistryChromosome instabilityCancerCancer researchGeneticsGeneCell cycleChromosomeUbiquitin and proteasome pathwaysMicrotubule and mitosis dynamicsEpigenetics and DNA Methylation