Carbonyl Reductase 1 Plays a Significant Role in Converting Doxorubicin to Cardiotoxic Doxorubicinol in Mouse Liver, but the Majority of the Doxorubicinol-Forming Activity Remains Unidentified
Daniel H. Breysse, Ryan M. Boone, Cameron M. Long, Miranda Merrill, Christopher M. Schaupp, Collin C. White, Terrance J. Kavanagh, Edward E. Schmidt, Gary F. Merrill
Topics & Concepts
DoxorubicinEnzymeChemistryBiochemistryPharmacologyCytosolBiologyMedicineInternal medicineChemotherapyChemotherapy-induced cardiotoxicity and mitigationMetal-Catalyzed Oxygenation MechanismsElectron Spin Resonance Studies