Litcius/Paper detail

Carbonyl Reductase 1 Plays a Significant Role in Converting Doxorubicin to Cardiotoxic Doxorubicinol in Mouse Liver, but the Majority of the Doxorubicinol-Forming Activity Remains Unidentified

Daniel H. Breysse, Ryan M. Boone, Cameron M. Long, Miranda Merrill, Christopher M. Schaupp, Collin C. White, Terrance J. Kavanagh, Edward E. Schmidt, Gary F. Merrill

2020Drug Metabolism and Disposition19 citationsDOIOpen Access PDF

Topics & Concepts

DoxorubicinEnzymeChemistryBiochemistryPharmacologyCytosolBiologyMedicineInternal medicineChemotherapyChemotherapy-induced cardiotoxicity and mitigationMetal-Catalyzed Oxygenation MechanismsElectron Spin Resonance Studies