Malononitrile-activated synthesis and anti-cholinesterase activity of styrylquinoxalin-2(1<i>H</i>)-ones
Sheena Mahajan, Nancy Slathia, Vijay K. Nuthakki, Sandip B. Bharate, Kamal K. Kapoor
Abstract
cholinesterase inhibition and 4n was found to display a mixed type of inhibition of AChE, which was supported by molecular modelling studies. This study has led to the discovery of a new chemotype for cholinesterase inhibition which might be useful in finding a remedy for Alzheimer's disease.
Topics & Concepts
MalononitrileKnoevenagel condensationChemistryCholinesteraseYield (engineering)ArylOrganic chemistryCombinatorial chemistryPharmacologyCatalysisBiologyMaterials scienceMetallurgyAlkylSynthesis and Biological EvaluationCholinesterase and Neurodegenerative DiseasesMulticomponent Synthesis of Heterocycles