Long non-coding RNA lnc-CCNL1-3:1 promotes granulosa cell apoptosis and suppresses glucose uptake in women with polycystic ovary syndrome
Jiayu Huang, Jun Zhao, Xueying Geng, Weiwei Chu, Shang Li, Zi‐Jiang Chen, Yanzhi Du
Abstract
overexpression upregulated FOXO1 expression, promoted cell apoptosis, reduced glucose transport capability, and impaired mitochondrial function, and these effects were partially abolished by silencing FOXO1. The interaction of CCNL with FOXO1 might prevents FOXO1 exclusion from the nucleus and subsequent degradation in the cytosol. We determined that CCNL serve as a facilitator in the processes of PCOS. CCNL might participate in PCOS pathologies such as follicular atresia and insulin resistance.
Topics & Concepts
Polycystic ovaryBiologyFOXO1Long non-coding RNAGranulosa cellDownregulation and upregulationGene silencingEndocrinologyInternal medicineInsulin resistanceCell biologyCancer researchFollicular phaseSignal transductionInsulinMedicineGeneGeneticsProtein kinase BCancer-related molecular mechanisms researchLipid metabolism and disordersKruppel-like factors research