Development of an electrochemical sensor based on Ni-Bio-MOF and a molecular imprinted polymer for determination of diclofenac: electrochemical and DFT investigations
Samaneh Ebadi, Kh. Ghanbari, Mansoureh Zahedi-Tabrizi
Abstract
, relative standard deviation (RSD) of 3.3%, and reproducibility of 96.2%. Real samples of healthy human blood serum and DCF tablets were used to evaluate the practical application of the CPE/Ni-Bio-MOF/MIP-PL-Met electrochemical sensor. This method is simple, low-cost, with good limited detection, high sensitivity, and selectivity. The interactions of PL-Met with DCF were studied at the B3LYP/6-311++G(d,p) level of theory in both gaseous and aqueous phases. Additionally, the computational methodology investigated the thermodynamic stability of the proposed configurations and the role of hydrogen bonds in this system.
Topics & Concepts
ElectrochemistryElectrochemical gas sensorMolecularly imprinted polymerNanocompositeDiclofenacMaterials scienceElectrodePolymerChemical engineeringNanotechnologyChemistryOrganic chemistrySelectivityCatalysisPhysical chemistryComposite materialEngineeringBiochemistryAnalytical chemistry methods developmentAdvanced biosensing and bioanalysis techniquesAnalytical Chemistry and Chromatography