A molecular hybridization approach for the design of selective aldose reductase (ALR2) inhibitors and exploration of their activities against protein tyrosine phosphatase 1B (PTP1B)
Antonios Kousaxidis, Anthi Petrou, Philippa Rouvim, Pavol Boďo, Milan Štefek, Ioannis Nicolaou, Athina Geronikaki
Topics & Concepts
Aldose reductaseAldehyde ReductaseChemistryPolyol pathwayBiochemistryAldose reductase inhibitorEnzymeEnzyme inhibitorAldo-keto reductaseReductaseStereochemistryAldose Reductase and TaurineEicosanoids and Hypertension PharmacologyCancer, Hypoxia, and Metabolism