A Novel, Extremely Bioavailable Cocrystal of Pterostilbene
Lídia Bofill, Rafael Barbas, Dafne de Sande, Mercè Font-Bardı́a, Clara Ràfols, Joan Albertí, Rafel Prohens
Abstract
New multicomponent solid forms of the nutraceutical pterostilbene have been discovered and characterized through experimental cocrystal screening. Among the coformers tested, picolinic acid formed a cocrystal with a 10-fold enhancement of oral bioavailability in rats, which converts the new cocrystal into a very promising candidate for new formulations of pterostilbene with improved performance.
Topics & Concepts
CocrystalPterostilbeneBioavailabilityNutraceuticalChemistryPicolinic acidCombinatorial chemistryOrganic chemistryPharmacologyBiochemistryResveratrolBiologyMoleculeHydrogen bondCrystallography and molecular interactionsEnergetic Materials and CombustionEnzyme Structure and Function